Stevia Rebaudiana Studies

Rebaudioside A Potently Stimulates Insulin Secretion From Isolated Mouse Islets:Studies on the Dose-, Glucose-, and Calcium-Dependency 2004  [PDF]

Extracts of leaves of the plant Stevia rebaudiana Bertoni (SrB), have been used for many years in traditional treatment of diabetes in South America. Stevia leaves contain diterpene glycosides, stevioside and rebaudioside A being the most abundant. Recently, it was demonstrated that stevioside stimulates the insulin secretion both in vitro and in vivo. Subse- quently, we wanted to elucidate the influence of rebaudioside A on the insulin release from mouse islets using static incubations, as well as perifusion experiments. Rebaudioside A (10